1. 个人简介：

荆新云博士，副研究员，硕士生导师

教育经历：

2009-2013，博士，中国科学院大学

2006-2009，硕士，华东理工大学

2002-2006，学士，河南大学

工作经历：

2025-至今，上海师范大学 副研究员

2018-2024，中国科学院分子植物科学卓越创新中心，副研究员

2013-2018，中国科学院上海植物生理生态研究所，助理研究员

2. 主要研究方向：

[1] 表观合成生物学：RNA编辑、核小体起源与演化。

[2] 微生物天然药物研发。

3. 代表性科研项目：

[1] 基于BioNano技术分析复杂基因组结构变异的生物信息学解析体系及在水稻中的应用，国家自然科学基金（青年基金），2015-2017。

[2]原核生物基因组的人工模块化与简约化，科技部重点研发计划子课题， 2019-2024

[3]真核生物古菌祖先的基因组特征与衍生类群的发现，国家自然科学基金重大项目子课题，2024-2028

4. 代表性论文及著作：

[1]Xinyun Jing^#, Xiaojuan Zhou^#, Niubing Zhang^#, Ping Chen^#, Jie Gong^#, Kaixiang Zhang, Xueting Wu, Wenjuan Cai, Bang-ce Ye, Pei Hao, Guo-ping Zhao, Sheng Yang, Xuan Li^*. Creating a bacterium that forms eukaryotic nucleosome core particles. Nature Communications. 2024; 15(1):8283.

[2]Xiaojuan Zhou^#, Niubing Zhang^#, Jie Gong, Kaixiang Zhang, Ping Chen, Xiang Cheng, Bang-Ce Ye, Guoping Zhao^*, Xinyun Jing^*, Xuan Li^*. (2024) In vivo assembly of complete eukaryotic nucleosomes and (H3-H4)-only non-canonical nucleosomal particles in the model bacterium Escherichia coli. Communications Biology. 2024; 7(1):1510.

[3]Niubing Zhang^#, Ping Chen^#, Zilin Cui, Xiaojuan Zhou, Chenhui Hao, Bingran Xie, Pei Hao, Bang-Ce Ye^*, Xuan Li^*, Xinyun Jing^*. Revealing differential RNA editing specificity of human ADAR1 and ADAR2 in Schizosaccharomyces pombe. Genes.2024; 15(7):898.

[4]Longxian Chen^#, Liang Ou^#, Xinyun Jing^#, Yimeng Kong^#, Bingran Xie, Niubing Zhang, Han Shi,Hang Qin, Xuan Li^*, and Pei Hao^*. DeepEdit: single-molecule detection and phasing of A-to-I RNA editing events using nanopore direct RNA sequencing. Genome Biology, 2023; 24(1):75.

[5]Ping Chen#, Minjie Chen#, Yujie Chen#, Xinyun Jing#, Niubing Zhang, Xiaojuan Zhou , Xuan Li*, Gang Long*, Pei Hao*.Targeted inhibition of Zika virus infection in human cells by CRISPR-Cas13b.Virus Research, 2022; 312:198707.

[6]Niubing Zhang# , Xinyun Jing# , Yuanhua Liu, Minjie Chen, Xianfeng Zhu, Jing Jiang , Hongbing Wang, Xuan Li*, Pei Hao*. Interfering with retrotransposition by two types of CRISPR effectors: Cas12a and Cas13a. Cell Discovery,2020; 19:6:30.

[7]Xinyun Jing#, Bingran Xie#, Longxian Chen, Niubing Zhang, Yiyi Jiang,  Hang Qin, Hongbing Wang, Pei Hao*, Sheng Yang*, Xuan Li*. Implementation of the CRISPR-Cas13a system in fission yeast and its repurposing for precise RNA editing. Nucleic Acids Research, 2018; 46(15):e90.

[8]Ping Chen#, Xinyun Jing, Ren Jian, Cao Han, Pei Hao, Xuan, Li*. Modeling BioNano optical data and simulation study of genome map assembly. Bioinformatics, 2018; 34(23):3966-3974.

[9]Ping Chen#, Xinyun Jing#, BaoSheng Liao, Yan Zhu, Jiang Xu, Renyi Liu, Yinhong Zhao, Xuan Li*. BioNano genome map resource for Oryza sativa ssp. japonica and indica and its application in rice genome sequence correction and gap filling. Molecular Plant, 2017; 10(6):895-898.

[10]Yan Zhu#, Longxian Chen#, Chengjun Zhang, Pei Hao, Xinyun Jing*, Xuan Li*. Global transcriptome analysis reveals extensive gene remodeling, alternative splicing and differential transcription profiles in non-seed vascular plant Selaginella moellendorffii. BMC Genomics,2017; 18(Suppl 1):1042.

[11]Yimeng Kong#, Peng Xu#, Xinyun Jing, Longxian Chen, Laigeng Li, Xuan Li*. Decipher the ancestry of the plant-specific LBD gene family. BMC Genomics, 2017; 18(Suppl 1):951.

[12]Min Zhou#, Xinyun Jing#, Pengfei Xie#, Weihua Chen, Tao Wang, Haiyang Xia, Zhongjun Qin*. Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor. FEMS Microbiology Letters,2012; 333(2):169-79.

[13]Xinyun Jing, Xiaoxi Zhang, Jie Bao*. Inhibition performance of lignocellulose degradation products on industrial cellulase enzymes during cellulose hydrolysis. Applied Biochemistry and Biotechnology, 2009; 159:696-707

5. 获奖情况：

[1]上海市生物工程学会“曼森”生物工程优秀青年科学家奖, 2024；

6. 代表性授权专利：

[1]李轩、荆新云、张牛冰，基于CRISPR-Cas13a干预阻断病毒转座的技术，ZL202010321800.9；

[2]李轩、荆新云、张牛冰，基于CRISPR-Cas13a的RNA定点编辑技术，ZL201810503339.1；

[3]李轩、唐桂月、荆新云，APOBEC3A的RNA脱氨酶活性测定方法及RNA高活性的APOBEC3A变体， ZL202110477071.0；

[4]李轩、张牛冰、荆新云，基于CRISPR-Cas12a干预阻断病毒转座的技术， ZL202010321783.9；

[5]李轩、荆新云、余曜、戴小密，豆科植物叶片组织特异性启动子及其应用，ZL201510064426.8

更新时间：2025年3月