1.个人简介：
袁华，博士，研究员，微生物学专业硕士/博士生导师。研究方向为微生物药物的创新发现与智造，相关研究理论对天然产物药学研究中重点关注的新颖结构的发现、创制以及复杂化合物的高效制备等均具有重要的推动作用。研究成果已发表在Nature communications、Natural product reports、ACS synthetic biology等国际知名期刊上。主持或参与国家自然科学基金、国家重点研发计划等基金项目多项。
邮箱：huayuan@shnu.edu.cn
教育及工作经历：
2020.7-至今，上海师范大学研究员
2014.5-2020.6，中国科学院上海有机化学研究所副研究员
2014.3-2014.5，中国科学院上海有机化学研究所助理研究员
2012.3-2014.3，中国科学院上海有机化学研究所博士后
2008-2012，博士，中国科学院上海植物生理生态研究所
2. 主要研究方向：
[1] 基因组信息指导的微生物活性天然产物挖掘
[2] 微生物活性天然产物的生物合成
[3] 抗生素高产菌株的创制
3. 代表性科研项目：
[1] 微生物药物工业底盘构建与适配性优化，国家重点研发计划项目，2021.07-2024.06，子课题负责人。
[2] 放线菌药物合成生物体系的网络重构与系统优化，国家重点研发计划项目，2020.01-2024.12，子课题负责人。
[3] 高活性苯并二吡咯类抗肿瘤抗生素的生物合成与新化合物挖掘，国家自然科学基金（面上项目），2019.01-2022.12，主持。
[4] 天然产物中新型三元环基团环丙基形成的酶催化过程研究，国家自然科学基金（青年科学基金项目），2016.01-2018.12，主持。
4. 代表性论文（#共同第一作者，*通讯作者）：
[13] Wang W, Ma N, Xu T, Wu YL, Zheng GS, Zou LS, Niu XL, Yang J, Zhao GP, Lu YH*, Yuan H*. Development and application of an ACQUIRE method for direct cloning of superlarge biosynthetic gene cluster. ACS synthetic biology 2025, 14:2480-2487.
[12] Liu X, Wang X, Shao Z, Dang J, Wang W, Liu C, Wang J*, Yuan H*, Zhao G. The global nitrogen regulator GlnR is a direct transcriptional repressor of the key gluconeogenic gene pckA in actinomycetes. Journal of bacteriology 2024, 206:e0000324.
[11] He J, Kang X, Wu J, Shao Z, Zhang Z, Wu Y, Yuan H*, Zhao G*, Wang J*. Transcriptional self-regulation of the master nitrogen regulator GlnR in Mycobacteria. Journal of bacteriology 2023, 205:e0047922.
[10] Wan J, Ma N, Yuan H*. Recent advances in the direct cloning of large natural product biosynthetic gene clusters. Engineering microbiology 2023, 3:100085.
[9] Zheng XF, Liu XQ, Peng SY, Zhou Q*, Xu B*, Yuan H*, Tang GL. Characterization of the rifamycin-degrading monooxygenase from rifamycin producers implicating its involvement in saliniketal biosynthesis. Frontiers in microbiology 2020, 11:971.
[8] Jin WB, Wu S, Xu YF, Yuan H*, Tang GL*. Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions. Natural product reports 2020, 37, 17-28.
[7] Jin WB, Wu S, Jian XH, Yuan H*, Tang GL*. A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropaneformation in natural product biosynthesis. Nature communications 2018, 9:2771.
[6] Wang X, Wu S, Jin W, Xu B*, Tang GL*, Yuan H*. Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin. Acta Biochimica et Biophysica Sinica 2018, 50, 516-518.
[5] Yuan H#, Zhang J#, Cai Y, Wu S, Yang K, Chan HCS, Huang W, Jin WB, Li Y, Yin Y, Igarashi Y, Yuan S, Zhou J, Tang GL. GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nature communications 2017, 8:1485.
[4] Wu S#, Jian XH#, Yuan H#, Jin WB, Yin Y, Wang LY, Zhao J, Tang GL. Unified biosynthetic origin of the benzodipyrrole subunits in CC-1065. ACS chemical biology 2017, 12, 1603-1610.
[3] Yang K, Qi LH, Zhang M, Hou XF, Pan HX, Tang GL, Wang W*, Yuan H*. The SARP family regulator Txn9 and two-component response regulator Txn11 are key activators for trioxacarcin biosynthesis in Streptomyces bottropensis. Current microbiology 2015, 71, 458-464.
[2] Yuan H, Zhao W, Zhong Y, Wang J, Qin Z, Ding X, Zhao GP. Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B. Acta Biochimica et Biophysica Sinica 2011, 43, 948-956.
[1] Zhao W#, Zhong Y#, Yuan H#, Wang J#, Zheng H, Wang Y, Cen X, Xu F, Bai J, Han X, Lu G, Zhu Y, Shao Z, Yan H, Li C, Peng N, Zhang Z, Zhang Y, Lin W, Fan Y, Qin Z, Hu Y, Zhu B, Wang S, Ding X, Zhao GP. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell research 2010, 20, 1096-1108.
更新时间：2025年10月
