
1. 个人简介:
俞芳,副研究员,生物化学专业硕士导师
教育经历:
2002-2005,硕士,复旦大学
1998-2002,学士,山东大学
工作经历:
2017-至今,上海师范大学 副研究员
2011-2017,中国科学院生化细胞所 副研究员
2008-2010,美国普林斯顿大学 研究助理
2005-2008,中科院神经所 研究助理
2. 主要研究方向:
植物蛋白质功能的研究。
3. 代表性科研项目:
[1]植物ECF转运蛋白的底物与功能鉴定,国家自然科学基金(面上项目),2025-2028,主持
[2]植物光信号感知与传递新蛋白质机器的挖掘和机制解析,国家重点研发项目,2024-2029,子课题负责人
[3]基于植物底盘的药用植物活性成分研究及其应用,国家重点研发项目,2019-2024,子课题负责人
[4]磷脂酶D的结构与分子机制研究,国家自然科学基金(面上项目),2020-2023,主持
[5]线粒体Ups蛋白转运磷脂的分子机理研究,国家自然科学基金(青年项目),2015-2017,主持
[6]叶绿体重要生理过程蛋白质的结构与机理解析,科技部青年973项目,2015-2019,骨干
4. 代表性论文及著作:
论文
Fang S., Zhao Y., Zhang X., YuF.*, Zhang P.*. Molecular mechanism underlying phosphate distribution by SULTR family transporter SPDT in Oryza sativa. Sci Adv. 2025. 11(41):eady3442.doi: 10.1126/sciadv.ady3442.
Fang S.#, Yang Y.#, Zhang X.#, Yang Z., Zhang M.H., Zhao Y., Zhang C.S., Yu F., Wang Y.F.*, Zhang P.*.Structural mechanism underlying PHO1;H1 mediated phosphate transport in Arabidopsis. Nat Plants. 2025a.doi:10.1038/s41477-024-01895-6.
Hong S.#,Guo J.#,Zhang X.,Zhou X.,Zhang P.,Yu F.*; Structural basis of phosphorylation-induced activation of the response regulator VbrR. Acta Biochimica et Biophysica Sinica, 2023, 55(1):43-50.
Yang Z.#, Zhang X.#, Ye S.W.#, Zheng J.T., Huang X.W., Yu F., Chen Z.G.*, Cai S.Q.*, Zhang P.*. Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun. 2023. 14(1): 4879. doi: 10.1038/s41467-023-40624-z
Fang S. #, Huang X.W.#, Zhang X.#,*, Zhang M.H., Hao YH, Guo H., Liu L.N., Yu F., Zhang P*.Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA.Proc Natl Acad Sci U S A. 2021.118 (22) e2101632118. doi: 10.1073/pnas.2101632118.
Shao K. #, Zhang X. #, Li X. #, Hao Y.H., Huang X.W., Ma M.L., Zhang M.H., Yu F., Liu H.T.*, Zhang P.*.The oligomeric structures of plant cryptochromes. Nat. Struct. Mol. Biol. 2020. 27(5): 480-488.doi: 10.1038/s41594-020-0420-x.(Views and News in NSMB)
Li J.X.#, Yu F.#, Guo H., Xiong R.X., Zhang W.J., He F.Y., Zhang M.H., Zhang P. Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Res. 2020.30(1): 61-69. doi: 10.1038/s41422-019-0244-6.
Wang C.C., Sun B., Zhang X., Huang X.W., Zhang M.H., Guo H., Chen X., Huang F., Chen T.Y., Mi H.L., Yu F., Liu L.N., Zhang P.*.Structural mechanism of the active bicarbonate transporter from cyanobacteria. Nat Plants. 2019. 5(11):1184-1193.doi: 10.1038/s41477-019-0538-1.
Yu F.#, He F.Y. #, Yao H.Y., Wang C.Y., Wang J.C., Li J.X., Qi X.F., Xue H.W.*, Ding J.P.*, Zhang P.*. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. EMBO Rep. 2015. 16 (7). 813-823. doi: 10.15252/embr.201540137. (Recommended by Faculty 1000, Biology)
Xu K. #, Zhang M.H. #, Zhao Q. #, Yu F. #, Guo H., Wang C.Y., He F.Y., Ding J.P., Zhang P*. Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature. 2013. 497(7448):268-271. doi: 10.1038/nature12046.
GrecoT.M.#, Yu F. #, Guise AJ., Cristea I.M*. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.Mol Cell Proteomics,2011, 10(2):M110.004317.
Guise AJ.,Mathias R.M., Rowland E.A., Yu F., Cristea I.M.*, Probing phosphorylation-dependent protein interactions within functional domains of histone deacetylase 5 (HDAC5),Proteomics,2014, 14(19):2156-2166
Joshi P, Greco T. M, Guise AJ., Luo Y., Yu F., Nesvizhskii A.I, Cristea I.M.*, The functional interactome landscape of the human histone deacetylase family,Mol Syst Biol, 2013, 9:672
Guise AJ.,Greco T. M., Zhang I.Y , Yu F.,Cristea I.M.*. Aurora B-dependent regulation of class IIa histone deacetylases by mitotic nuclear localization signal phosphorylation, Mol Cell Proteomics, 2012, 11(11):1220-1229
更新时间:2025年10月


